Cupramine is superior to copper sulfate, chloride & citrate: it is non-acidic, less toxic to fish, remains in solution, and does not contaminate the filter bed. It is superior to chelates: it is fully charged (ionic), and active at low concentrations, and is removable with carbon.
Do not use in conjunction with any other medication. If tank has ever been treated with an ionic copper (e.g. copper chloride, sulfate or citrate), test copper level after initial dosing.